Biochemical Polymorphisms in Reddy Population of Visakhapatnam District in South India

Introduction: The investigation of human blood genetic markers is a convenient tool to study genetic variation within and between human populations. The present investigation reports the variation in the distribution of some genetic markers (blood groups, plasma proteins and red cell enzymes) in Reddy, an endogamous population from State of Andhra Pradesh, India. Methods: Eighty venous blood samples collected from health and unrelated individuals living in Visakhapatnam city were used for typing eight genetic markers- two blood group systems namely ABO and Rh (D), four serum proteins which include Albumin(ALB), Haptoglobin(HP), Caeruloplasmin (CP), Group Specific Component(GC), and two red cell enzymes Esterase D (ESD), Superoxide Dismutase(SOD). The gene frequencies were estimated and goodness of fit between the observed and expected phenotype frequencies was also tested. Results: The frequency of ‘A’ group is found to be predominant recording a frequency of 50% which was followed by ‘AB’ group with a frequency of 26.25. ‘O’ group shows the least frequency with 5%. The homogeneity test for goodness of fit between observed and expected phenotypes is statistically significant (χ² = 9.2037; d.f = 1; 0.01 > p > 0.001) in Reddy’s with respect to ESD system and HP system (χ² = 20.2780; d.f = 1; 0.001 > p) and non-significant with respect to GC system. The Caeruloplasmin (CP) and Albumin (ALB) locus were monomorphic in the present study. Conclusions: The results of these biochemical genetic markers were found to be in accordance with other populations of Andhra Pradesh.