Daturas belong to the tropane Solanaceous group of plants, traditionally used in the Old and New World for their intoxicant properties. In Africa two species – Datura stramonium, and D. metel – are used in religious, initiatory, divinatory, magic-therapeutic rites, and also as tools during trials by ordeal, in courts of law, and in criminal proceedings. The present study describes some African traditional cults and rites where daturas are involved, with a particular focus on the Bori possession cult among the Hausas of Niger, the feminine initiatory rite among the Tsongas of Mozambique, the ordeal ceremony among the Ba-Rongas of South Africa, the leba shay Abyssinian juridical institution, and the datura’s ritual complex of Senegalese marabouts.