Menopausal Transition and Women Health: A Study among the Mid-life Women of Kolkata, India

Women’s mid life through and after menopause is associated with somatic problems like obesity, loss of skeletal muscle and bone mass, cardiovascular diseases and hyperglycemia. The present study is an endeavour to understand the impact of menopausal transition on cardio vascular risk factors and musculoskeletal system among the 160 Bengali speaking Hindu mid-life women of Kolkata, India. Statistical analysis like bivariate statistics was applied to compare the body compositions and clinical variables between peri and postmenopausal participants. Receiver Operating Characteristic (ROC) curve analyses were performed to identify the discriminatory power of the obesity indicators. And to assess the determinants of hypertension and diabetes, multivariate logistic regression analysis was applied. Result showed that significant (p<0.05) peri-post menopausal differences existed in percent body fat (PBF), fat mass index (FMI), conicity index (CI), skeletal muscle percentage (SMP), bone mass (BM) and diastolic blood pressure (DBP).. PBF (r=0.24) showed positive but SMP (r= -0.46) and BM (r= -0.37) showed negative association (p<0.01) with increased chronological age. Area under the curve (AUC) found BMI (0.91) and CI (0.91) as the best indicator (p<0.001) of obesity among the perimenopausal participants and PBF (0.93) and FMI (0.93) among the postmenopausal participants. Thus, it can be concluded that the the menopausal transition phase brings changes in blood pressure, blood sugar level, SMP, BM and also in the overall and central adiposity markers.