The present study is carried out to understand the quality of life (QoL) among mothers having children with different types of neurodevelopmental disorders (NDD). The participants were randomly chosen one consisted of 120 mothers, 30 each having children with intellectual disability (ID), specific learning disability (SLD), attention deficit hyperactive disorder (ADHD) and autism spectrum disorder (ASD). Data are collected using WHOQOL-BREF. The analysis of data using one-way ANOVA revealed that mothers having children with ID and ASD report significantly more impairment in four domains (general health, physical health, environmental health and overall health) of QoL than mothers having children with ADHD and SLD.